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CVVH and intermittent HD have also been trialed in adult patients with other rare conditions characterized by hyperammonemia, but the generalizability of these studies is limited owing to the small number of patients (23,39). 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The 63-year-old actor cut a casual figure as he stepped out with his girlfriend, 43, with his precious pooch and they all enjoyed a relaxing stroll togetherKorotyayeva looked effortlessly chic in a casual fashion as she modeled a white button-down top teamed with cutoff denim shorts.On her feet, she donned a pair of all-white canvas sneakers for both comfort and style.Like Penn, she prepared for chilly weather and was seen carrying a black and white sweater. She left her dark brunette tresses down in a straight hairstyle and appeared to have forewent any makeup to showcase her natural beauty. Previously, the Oscar winner and his newfound love were first romantically linked when they were spotted leaving a restaurant together in Malibu together in late May.Prior to his romance with Korotyayeva, Penn dated Animal Kingdom actress George for four years before they tied the knot in July 2020.In September 2021, the couple split and George filed for divorce, citing irreconcilable differences, a month later.In April 2022, Penn admitted to Hollywood Authentic that he 'f***ed up the marriage' by being 'very neglectful' to George. Casual and relaxed: He sported a classic white T-shirt, cargo shorts and brown hiking boots as he walked side-by-side next to the Blast actress. For their daytime outing, he also carried with him an olive green jacket thrown over his shoulder as he walkedHis ex: The Mystic River star and Korotyayeva were walking the Golden Retriever he adopted in 2017 with his ex-wife, Leila George. Prior to his romance with Korotyayeva, Penn dated Animal Kingdom actress George for four years before they tied the knot in July 2020His former marriage: In September 2021, the couple split and George filed for divorce, citing irreconcilable differences, a month later. In April 2022, Penn admitted to Hollywood Authentic that he 'f***ed up the marriage' by being 'very neglectful' to GeorgeAt the time, he also said he was still very much in love with her. 'There's a woman who I'm so in love with, Leila George, who I only see on a day-to-day basis now, because I f***ed up the marriage,' he told the outlet.'We were married technically for one year, but for five years, I was a very neglectful guy,' he confessed.He said he was faithful to her but did not spend quality time with her near the end of their relationship.'I was not a f***ing cheat or any of that obvious s***,' he said. 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